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SML2925

Sigma-Aldrich

MESM

≥98% (HPLC)

Synonym(s):

5′-(2-Hydroxyphenyl)-1-methylspiro[3H-indole-3,2′(3′H)-[1,3,4]thiadiazol]-2(1H)-one, Manganese-Extracting Small Molecule, VU0028386

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About This Item

Empirical Formula (Hill Notation):
C16H13N3O2S
CAS Number:
360572-26-5
Molecular Weight:
311.36
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

S1C2(NN=C1c4c(cccc4)O)c3c(cccc3)N(C2=O)C

InChI

1S/C16H13N3O2S/c1-19-12-8-4-3-7-11(12)16(15(19)21)18-17-14(22-16)10-6-2-5-9-13(10)20/h2-9,18,20H,1H3

Biochem/physiol Actions

MESM is a cell penetrant and non-toxic selective manganese ionophore that potently facilitates of manganese export from cells. MESM can be used to rapidly extract and quantify cellular manganese content in a non-lethal and selective MESMER (Manganese-Extracting Small Molecule Estimation Route) assay. MESM does not impacted Fura-2 AM fluorescence.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Kyle J Horning et al.
The Journal of biological chemistry, 295(12), 3875-3890 (2020-02-13)
Available assays for measuring cellular manganese (Mn) levels require cell lysis, restricting longitudinal experiments and multiplexed outcome measures. Conducting a screen of small molecules known to alter cellular Mn levels, we report here that one of these chemicals induces rapid

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