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SML1097

Sigma-Aldrich

BC8-15

≥98% (HPLC)

Synonym(s):

3-[(3-Ethyl-1,2,4-triazolo[4,3-c]quinazolin-5-yl)amino]-benzoic acid

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About This Item

Empirical Formula (Hill Notation):
C18H15N5O2
CAS Number:
950385-77-0
Molecular Weight:
333.34
UNSPSC Code:
41106305
PubChem Substance ID:
329825474
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

CCC1=NN=C2N1C(NC3=CC=CC(C(O)=O)=C3)=NC4=CC=CC=C42

InChI

1S/C18H15N5O2/c1-2-15-21-22-16-13-8-3-4-9-14(13)20-18(23(15)16)19-12-7-5-6-11(10-12)17(24)25/h3-10H,2H2,1H3,(H,19,20)(H,24,25)

InChI key

INDKHRIZOIEPIG-UHFFFAOYSA-N

Biochem/physiol Actions

BC8-15 has the ability to block PDE8A (phosphodiesterase 8A) and PDE4A (phosphodiesterase 4A) with IC50 values of 280 and 220 nM. It helps to increase the synthesis of the steroid from both primary Leydig cells and MA-10 cells.
BC8-15 is a potent PDE4/8 inhibitor that elevates steroidogenesis in mouse Leydig cells.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Didem Demirbas et al.
PloS one, 8(8), e71279-e71279 (2013-08-24)
A cell-based high-throughput screen (HTS) was developed to detect phosphodiesterase 8 (PDE8) and PDE4/8 combination inhibitors. By replacing the Schizosaccharomyces pombe PDE gene with the murine PDE8A1 gene in strains lacking adenylyl cyclase, we generated strains whose protein kinase A

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