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About This Item
Empirical Formula (Hill Notation):
C68H92N14O15S2
Molecular Weight:
1409.67
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥67%
storage condition
protect from light
storage temp.
−20°C
Amino Acid Sequence
Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp
Application
IRL-1038 is used as a specific endothelin-B receptor (ET(B)-R) antagonist/blocker.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Hung-Tien Kuo et al.
The Kaohsiung journal of medical sciences, 22(8), 371-376 (2006-08-17)
Angiotensin II (Ang-II) is a potent vasoactive hormone, which plays an important role in the pathogenesis of glomerulosclerosis. Ang-II activates many cytokine systems in the kidney. Recent studies indicate that Ang-II is closely related to the activation of the endothelin-1
Noreen F Rossi
American journal of physiology. Endocrinology and metabolism, 286(4), E535-E541 (2003-12-11)
The endothelins (ET) have been implicated in vasopressin (AVP) release in vivo and in vitro. The effects of ET in this system are complex, and the net AVP secretory response likely depends on a unique combination of ET isoform, ET
Guo-lin Zhang et al.
Acta pharmacologica Sinica, 32(2), 223-229 (2011-02-05)
To investigate which endothelin receptors mediated isoproterenol (ISO)-induced downregulation of FKBP12.6/12 in cardiomyocytes and study whether argirhein, a novel compound containing rhein and L-arginine that has anti-inflammatory activity, could reverse the downregulation of FKBP12.6/12 induced by ISO. Neonatal rat cardiomyocytes
Changaram S Venugopal et al.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 70(1), 50-57 (2006-03-22)
The purpose of this study was to evaluate the role of endothelin-1 (ET-1) and its receptors in the airway hyperreactivity of horses with obstructive pulmonary disease associated with summer pasture (SPAOPD). The right diaphragmatic lobe of the lung of 8
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