SAB5701957

Anti-Phospho-CGAS-S420 antibody produced in rabbit

• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• Quality Level: 100
• antibody product type: primary antibodies
• clone: polyclonal
• form: liquid
• species reactivity: mouse, human, rat
• concentration: 0.755 mg/mL
• technique(s): immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• UniProt accession no.: Q8C6L5
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer420)
• Gene Information: mouse ... CGAS(214763)

Description

General description

The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Immunogen

A phospho synthetic peptide corresponding to residues surrounding S420 of Mouse CGAS.

Physical form

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable