SAB4700391

Monoclonal Anti-CD11c-APC antibody produced in mouse

clone BU15, purified immunoglobulin, buffered aqueous solution

• Synonym(s): Anti-ITGAX
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: Allophycocyanin conjugate
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: BU15, monoclonal
• form: buffered aqueous solution
• species reactivity: human, monkey, canine
• technique(s): flow cytometry: suitable
• isotype: IgG1
• NCBI accession no.: NM_000887.3
• UniProt accession no.: P20702
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... ITGAX(3687)

Description

General description

Cluster of differentiation 11c (CD11c), also known as integrin subunit α X (ITGAX), is an antigen receptor, encoded by the gene mapped to human chromosome 16p11.2. The encode protein belongs to the adhesion molecule integrin family and is mainly expressed in natural killer cells, macrophages and even some activated B and T cells.

The antibody BU15 reacts with CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages.

Immunogen

Dendritic cells of synovial fluid

Application

The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (1 mL) is sufficient for 100 tests.

Biochem/physiol Actions

Cluster of differentiation 11c (CD11c) delivers co-stimulatory signals to activated lymphocytes. Elevated expression of the gene decreased the risk of death and relapse in gastric cancer (GC) patients. The protein can be considered as an alternative prognosis marker for GC. Overexpression of CD11c in CD8⁺ cells might lead to the development of Behcet′s disease (BD).

Features and Benefits

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Physical form

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable