P7505

Putrescine dihydrochloride

≥98% (TLC), powder

• Synonym(s): 1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tetramethylenediamine dihydrochloride
• Linear Formula: NH₂(CH₂)₄NH₂ · 2HCl
• CAS Number: 333-93-7
• Molecular Weight: 161.07
• Beilstein: 3906680
• EC Number: 206-375-9
• MDL number: MFCD00012526
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278650
• NACRES: NA.77

Properties

• product name: Putrescine dihydrochloride, ≥98% (TLC)
• Assay: ≥98% (TLC)
• form: powder
• mp: 280 °C (dec.) (lit.)
• solubility: H₂O: soluble 100 mg/mL, clear, colorless
• SMILES string: Cl[H].Cl[H].NCCCCN
• InChI: 1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H
• InChI key: XXWCODXIQWIHQN-UHFFFAOYSA-N

Description

Application

Putrescine dihydrochloride has been used:

• as a bioactive amine standard in high-performance liquid chromatography (HPLC)
• as a component of hormone mix supplemented to Dulbecco′s modified eagle medium (DMEM) to study its effects on neural stem cells
• as a supplement in DMEM for culturing of endometrial cancer cells

Biochem/physiol Actions

Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.

Putrescine is an aliphatic amine and is positively charged. It acts as a precursor of spermine and plays a role in polyamine biosynthesis. Putrescine is found in several plants, animals, and bacteria. It plays a role in cell proliferation and cell growth in Escherichia coli. Putrescine is a component of agrochemicals, surfactants, pharmaceuticals, polymers, and additives.

Safety Information

• Pictograms: GHS06,GHS05
• Signal Word: Danger
• Hazard Statements: H302,H311,H314,H330
• Precautionary Statements: P260 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 1
• Flash Point(F): 113.0 °F - closed cup
• Flash Point(C): 45 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves