I1786
ID-8
≥98% (HPLC)
Synonym(s):
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
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About This Item
Empirical Formula (Hill Notation):
C16H14N2O4
CAS Number:
Molecular Weight:
298.29
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
COc1ccc(cc1)-n2c(C)c([N+]([O-])=O)c3ccc(O)cc23
InChI
1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3
InChI key
VVZNWYXIOADGSW-UHFFFAOYSA-N
General description
ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).
Biochem/physiol Actions
ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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