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Key Documents

G5889

Sigma-Aldrich

L-Glutamic acid monosodium salt hydrate

BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%

Synonym(s):

(S)-2-Aminopentanedioic acid, L-Glutamic acid monosodium salt, Glu, MSG, Monosodium glutamate

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About This Item

Empirical Formula (Hill Notation):
C5H8NNaO4 · xH2O
CAS Number:
Molecular Weight:
169.11 (anhydrous basis)
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.75

product line

BioReagent

Quality Level

Assay

≥99%

form

powder

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

color

white to off-white

mp

163 °C

InChI

1S/C5H9NO4.Na.H2O.H/c6-3(5(9)10)1-2-4(7)8;;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2;

InChI key

JYDGDQPVBSBYRT-UHFFFAOYSA-N

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General description

L-Glutamic acid/monosodium glutamate (MSG) is the sodium salt of glutamic acid. It is a commonly used food additive.

Application

L-Glutamic acid monosodium salt hydrate has been used:
  • to prepare glutamate stock solution in HEPES-buffered saline (HBS) for glutamate perfusions
  • as a component in YNG (yeast nitrogen base glutamate) medium
  • used to treat HT22 hippocampal cells to study its effects on cell viability and to examine the expression of molecules related to apoptotic cell death
  • as a component of fresh media to culture neurons and to assess glutamate uptake

Biochem/physiol Actions

Monosodium glutamate (MSG) is a food additive and an environmental agent, that can affect inflammation.
Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Monosodium glutamate (MSG): a villain and promoter of liver inflammation and dysplasia
Nakanishi Y, et al.
Journal of Autoimmunity, 30(1-2), 42-50 (2008)
Single-step marker switching in Schizosaccharomyces pombe using a lithium acetate transformation protocol
Brown S D and Lorenz A
Bio-protocol, 6(24) (2016)
Neuroprotective effects of 2, 3, 5, 4?-tetrahydoxystilbene-2-O-beta-D-glucoside from Polygonum multiflorum against glutamate-induced oxidative toxicity in HT22 cells
Lee S Y, et al.
Journal of Ethnopharmacology, 195, 64-70 (2017)
Neuroprotective actions of noradrenaline: effects on glutathione synthesis and activation of peroxisome proliferator activated receptor delta
Madrigal J LM, et al.
Journal of Neurochemistry, 103(5), 2092-2101 (2007)
Microfluidic local perfusion chambers for the visualization and manipulation of synapses
Taylor A M, et al.
Neuron, 66(1), 57-68 (2010)

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