D7159
2′,3′-Dideoxycytidine 5′-triphosphate sodium salt
≥90% (HPLC)
Synonym(s):
ddCTP
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About This Item
Empirical Formula (Hill Notation):
C9H16N3O12P3
CAS Number:
Molecular Weight:
451.16
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
Recommended Products
biological source
synthetic (organic)
Assay
≥90% (HPLC)
form
powder
solubility
water: 1 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
[Na+].NC1=NC(=O)N(C=C1)[C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2
InChI
1S/C9H16N3O12P3.Na/c10-7-3-4-12(9(13)11-7)8-2-1-6(22-8)5-21-26(17,18)24-27(19,20)23-25(14,15)16;/h3-4,6,8H,1-2,5H2,(H,17,18)(H,19,20)(H2,10,11,13)(H2,14,15,16);/q;+1/p-1/t6-,8+;/m0./s1
InChI key
LOOMQRBEBYCFPP-QDOHZIMISA-M
Application
Complexes of ddCTP with DNA polymerase β were studied by x-ray crystallography, with implications for inhibitory activity against HIV reverse transcriptase.
Biochem/physiol Actions
Inhibitor of DNA polymerase I-catalyzed chain elongation.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Georges Massiot et al.
Journal of natural products, 68(7), 979-984 (2005-07-26)
Five new acylphloroglucinol derivatives, mahureones A-E (1, 3-6), have been isolated from the leaves of Mahurea palustris, and their structures determined by spectroscopic means. During the isolation process, several byproducts (7-9) were formed by reaction of one of the isoprenyl
Yaligara Veeranagouda et al.
BMC genomics, 15, 429-429 (2014-06-06)
Bacteroides fragilis is a Gram-negative anaerobe that is normally a human gut commensal; it comprises a small percentage of the gut Bacteroides but is the most frequently isolated Bacteroides from human infections. Identification of the essential genes necessary for the
Michal R Szymanski et al.
The EMBO journal, 34(14), 1959-1970 (2015-06-10)
The human DNA polymerase gamma (Pol γ) is responsible for DNA replication in mitochondria. Pol γ is particularly susceptible to inhibition by dideoxynucleoside-based inhibitors designed to fight viral infection. Here, we report crystal structures of the replicating Pol γ-DNA complex
Nutjaree Jeenduang et al.
Clinica chimica acta; international journal of clinical chemistry, 442, 36-43 (2015-01-17)
Cardiovascular disease (CVD) is one of the major causes of death worldwide. Numerous genetic risk factors in lipid metabolism, including mutations of LDLR, APOB, and PCSK9, as well as polymorphisms of CETP and APOE, have been found to associate with
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