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Key Documents

C3595

Sigma-Aldrich

Anti-Connexin-32 (106-124) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CMTX, Anti-CMTX1, Anti-CX32

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About This Item

MDL number:
MFCD01633266
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 27 kDa

species reactivity

mouse, human, rat

technique(s)

immunohistochemistry (frozen sections): 1:400 using frozen rat liver sections
western blot: 1:400 using a rat liver membrane preparation

UniProt accession no.

P08034

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GJB1(2705)
mouse ... Gjb1(14618)
rat ... Gjb1(29584)

General description

Connexins (Cx) are a multi-gene family of highly related proteins with molecular weights ranging from 26 to 70 kDa. The structure of connexin molecules includes a cytoplasmic N-terminal region, four transmembrane domains, two extracellular loops, and a C-terminal cytoplasmic tail of varying length. The 27kD connexin protein (connexin 32, Cx32) is expressed in several tissues.

Immunogen

synthetic human connexin-32 peptide (amino acids 106-124).

Application

Anti-Connexin 32 (265-279) antibody produced in rabbit is suitable for immunohistochemistry (frozen sections) at a dilution of 1:400 using frozen rat liver tissue. It is also suitable for western blot at a dilution of 1:400 using a rat liver membrane preparation.
Anti-Connexin-32 (106-124) antibody produced in rabbit has been used in:
  • western blotting
  • immunofluorescence
  • immunohistology

Biochem/physiol Actions

Cx32 mutations is associated with X-linked Charcot-Marie-Tooth (CMTX) disease, which leads to myelin disruption and axonal degeneration.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Transient, recurrent, white matter lesions in X-linked Charcot-Marie-Tooth disease with novel connexin 32 mutation
Hanemann CO, et al.
Archives of Neurology, 60(4), 605-609 (2003)
Connexins and their channels in cell growth and cell death
Vinken M, et al.
Cellular Signalling, 18(5), 592-600 (2006)
Hendryk Aurich et al.
Cell transplantation, 14(7), 497-506 (2005-11-16)
Although ex vivo culture of hepatocytes is known to impair functionality, it may still be considered as desirable to propagate or manipulate them in culture prior to transplantation into the host liver. The aim of this study was to clarify
Sarah Koenig et al.
Cell transplantation, 14(1), 31-40 (2005-03-26)
The mechanisms of donor hepatocyte integration into recipient liver are not fully understood. We investigated mechanisms of both the integration and interaction of transplanted hepatocytes with host liver cells as well as the repopulation of the host organ following intraportal
Cell junctions in the germinal epithelium may play an important role in spermatogenesis of the catfish P. fasciatum (Pisces, Siluriformes)
Batlouni SR, et al.
Journal of Molecular Histology, 36(1-2), 97-110 (2005)
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