BP932

Imipramine hydrochloride

British Pharmacopoeia (BP) Reference Standard

• Synonym(s): 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride
• Empirical Formula (Hill Notation): C₁₉H₂₄N₂ · HCl
• CAS Number: 113-52-0
• Molecular Weight: 316.87
• EC Number: 204-030-7
• MDL number: MFCD00012669
• UNSPSC Code: 41116107

Properties

• grade: pharmaceutical primary standard
• API family: imipramine
• form: powder
• quality: British Pharmacopoeia (BP) Reference Standard
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: BP
• application(s): pharmaceutical
• format: neat
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H
• InChI key: XZZXIYZZBJDEEP-UHFFFAOYSA-N
• Gene Information: human ... SLC6A2(6530) , SLC6A4(6532)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Imipramine hydrochloride BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Methadone Tablets

Methadone Injection

Methadone Oral Solution (1 mg per mL)

Lofepramine Tablets

Clomipramine Capsules

Methadone Concentrate for Oral Solution

Lofepramine Hydrochloride

Imipramine Tablets

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters with K_is of 7.7 nM and 67 nM, respectively. Has little effect on the dopamine transporter (K_i = 25 μM).

Packaging

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable