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Millipore

Astragaloside IV

>98.0%

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About This Item

Empirical Formula (Hill Notation):
C41H68O14
CAS Number:
84687-43-4
Molecular Weight:
784.97
MDL number:
MFCD16036240
UNSPSC Code:
41106200
PubChem Substance ID:
329765850
NACRES:
NA.85

Quality Level

100

Assay

≥98.0% (TLC)
>98.0%

form

powder

mp

295-296 °C (lit.)

SMILES string

CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]2[C@@H](O)C[C@@]3(C)[C@@H]4C[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@H]6C(C)(C)[C@H](CC[C@@]67C[C@@]47CC[C@]23C)O[C@@H]8OC[C@@H](O)[C@H](O)[C@H]8O

InChI

1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1

InChI key

QMNWISYXSJWHRY-YLNUDOOFSA-N

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Biochem/physiol Actions

Anti-inflammatory.

Other Notes

Chemical constituent of Astragali radix

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCB3090
BCCB2207
BCBX5957
BCBS9602V
BCBR2507V

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Dexin Li et al.
Pharmaceutical biology, 58(1), 89-97 (2020-01-08)
Context: Osteoarthritis (OA) is a degenerative arthrosis sickness. Astragaloside IV (AS-IV) functions by relieving inflammatory damage.Objective: We aimed to investigate the mechanism by which AS-IV protects ATD cells from lipopolysaccharide (LPS)-induced damage.Materials and methods: ATDC5 cells were transfected with miR-203
Dingkun Gui et al.
Cytokine, 61(3), 970-977 (2013-02-26)
Accumulating evidence suggests that inflammatory processes are involved in the development of diabetic nephropathy (DN). However, there are no effective interventions for inflammation in the diabetic kidneys. Here, we tested the hypothesis that Astragaloside IV(AS-IV), a novel saponin purified from
Mincai Li et al.
European journal of pharmacology, 696(1-3), 203-209 (2012-10-09)
Diabetic hyperglycemia causes a variety of pathological changes. Astragaloside IV (AS-IV) was widely used for the treatment of cardiovascular diseases in China. The aim of this study was to determine the effect of AS-IV on bone marrow mesenchymal stem cells
Yan-Xu Chang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 911, 71-75 (2012-12-12)
According to Traditional Chinese Medicine (TCM) theories, TCM with different meridian tropism have different therapeutic effects. In view of the meridian tropism of Astragalus membranaceus (Huangqi), astragaloside IV, one of the effective phytochemicals of Huangqi, was appointed and observed its
Min Li et al.
Neurochemistry international, 60(5), 458-465 (2012-02-22)
Inflammation injury plays a key role in the process of cerebral injury induced by ischemia/reperfusion (I/R). Thus, we studied the potential of astragaloside IV, one of the major and active components of the astragalus membranaceous, to protect rat against cerebral
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