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Key Documents

MAB3562

Sigma-Aldrich

Anti-Sodium/Iodine Symporter Antibody, clone 2-2

clone 2-2, Chemicon®, from mouse

Synonym(s):

Na+/I- Symporter, NIS

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2-2, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000453.1

UniProt accession no.

Q92911

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SLC5A5(6528)

Specificity

Sodium/Iodide Symporter (NIS)

Immunogen

Synthetic peptide corresponding to amino acids 37-54 of human NIS.

Application

Anti-Sodium/Iodine Symporter Antibody, clone 2-2 detects level of Sodium/Iodine Symporter & has been published & validated for use in IH & WB.
Immunoblotting. The antibody recognizes a major band at ~97 kDa and minor bands at 15 kDa, 30 kDa, 68 kDa and 160 kDa.

Immunohistochemistry on frozen tissues.

Optimal working dilutions must be determined by end user.

Physical form

Format: Purified

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S Micali et al.
The Journal of endocrinology, 216(2), 125-133 (2012-11-03)
Testicular cancer is the most frequent cancer in young men. The large majority of patients have a good prognosis, but in a small group of tumors, the current treatments are not effective. Radioiodine is routinely used in the treatment of
Elisa Sala et al.
Molecular cancer research : MCR, 6(5), 751-759 (2008-05-07)
BRAF-activating mutations have been reported in several types of cancer, including melanoma ( approximately 70% of cases), thyroid (30-70%), ovarian (15-30%), and colorectal cancer (5-20%). Mutant BRAF has constitutive kinase activity and causes hyperactivation of the mitogen-activated protein kinase pathway.
M R Castro et al.
The Journal of clinical endocrinology and metabolism, 84(8), 2957-2962 (1999-08-12)
The thyroid sodium-iodide symporter (NIS) is responsible for iodide concentrating ability within thyroid follicular cells. We sought to develop monoclonal antibodies against human NIS (hNIS) for use as reagents in structure-function studies of the protein, as well as potential tools

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