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MAB19294

Sigma-Aldrich

Anti-Integrin β1 Antibody, active β1 integrins, clone TASC/9D11

clone TASC/9D11, Chemicon®, from mouse

Synonym(s):

CD29

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

TASC/9D11, monoclonal

species reactivity

chicken

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable

isotype

IgG1

NCBI accession no.

NM_002211.2
NM_033666.1
NM_033667.1
NM_033668.1
NM_033669.1
NM_133376.1

UniProt accession no.

P05556

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ITGB1(3688)

Specificity

Reactive with the extracellular domain of chicken integrin beta 1

Immunogen

E10 chick brain glial cells
Epitope: active beta1 integrins

Application

Detect the Integrin β1 protein using this Anti-Integrin β1, active β1 integrins, clone TASC/9D11 validated for use in IP & ICC.
Western blot: Not effective

Immunocytochemistry

Immunoprecipitation

Biological activity: Functionally inhibits attachment to vitronectin. Activates attachment to other substrates.



Optimal working dilutions must be determined by end user.

Physical form

Format: Purified
Purified immunoglobulin. Liquid in 0.02M PB +0.25 M NaCl, pH=7.6 with 0.1% Sodium Azide.

Storage and Stability

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Vitronectin and thrombospondin promote retinal neurite outgrowth: developmental regulation and role of integrins.
Neugebauer, K M, et al.
Neuron, 6, 345-358 (1991)
L R Strachan et al.
Experimental cell research, 314(3), 441-452 (2007-11-27)
Cell migration is essential for proper development of numerous structures derived from embryonic neural crest cells (NCCs). Although recent work has shown that receptor recycling plays an important role in NCC motility on laminin, the molecular mechanisms regulating NCC motility
Combined integrin activation and intracellular cAMP cause Rho GTPase dependent growth cone collapse on laminin-1.
M L Lemons, M L Condic
Experimental neurology null
Cell-surface regulation of beta 1-integrin activity on developing retinal neurons.
Neugebauer, K M and Reichardt, L F
Nature, 350, 68-71 (1991)
Liliana Osório et al.
The International journal of developmental biology, 53(4), 641-648 (2009-02-28)
In the prospective lumbo-sacral region of the chick embryo, neurulation is achieved by cavitation of the medullary cord, a process called secondary neurulation. Neural crest cells (NCC) are generated in this region and they give rise to the same types
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