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Key Documents

04-294

Sigma-Aldrich

Anti-phosho-erbB2/Her2 (Tyr1112) Antibody, clone 19G5

clone 19G5, Upstate®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

19G5, monoclonal

species reactivity

canine, rat, mouse, human

manufacturer/tradename

Upstate®

technique(s)

ELISA: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_001005862.1
NM_004448.2

UniProt accession no.

P04626

shipped in

wet ice

target post-translational modification

phosphorylation (pTyr1112)

Gene Information

human ... ERBB2(2064)
mouse ... Erbb2(13866)

Specificity

Recognizes phosphorylated domain of erbB2/Her2 on Tyrosine 1112

Immunogen

KLH-conjugated synthetic peptide encompassing the surrounding amino acids of Tyr1112 in human erbB2/Her2

Application

Detect phosho-erbB2/Her2 (Tyr1112) using this Anti-phosho-erbB2/Her2 (Tyr1112) Antibody, clone 19G5 validated for use in ELISA & WB.

Quality

Routinely evaluated by immunoblot.

Target description

185 kDa

Physical form

Format: Purified

Analysis Note

Control
Includes EGF treated SKOV-3 lysate as a positive control

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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L N Klapper et al.
Cancer research, 60(13), 3384-3388 (2000-07-26)
Overexpression of HER-2/ErbB-2, a homologue of the epidermal growth factor receptor, is associated with poor prognosis, and an ErbB-2-specific antibody is therapeutic when administered to patients with metastatic breast cancer. To understand the mechanism underlying immunotherapy, we concentrated on antibody-
Leonie W Wahjudi et al.
International journal of cancer, 148(6), 1438-1451 (2020-09-20)
DNA sequencing and RNA sequencing are increasingly applied in precision oncology, where molecular tumor boards evaluate the actionability of genetic events in individual tumors to guide targeted treatment. To work toward an additional level of patient characterization, we assessed the
Erin-Mai F Lim et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(9), E1707-E1716 (2017-02-01)
AlphaB-crystallin (αBC) is a small heat shock protein that is constitutively expressed by peripheral nervous system (PNS) axons and Schwann cells. To determine what role this crystallin plays after peripheral nerve damage, we found that loss of αBC impaired remyelination

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