890898C

DOTMA

Avanti Research^™ - A Croda Brand

• Synonym(s): 1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)
• Empirical Formula (Hill Notation): C₄₂H₈₄ClNO₂
• CAS Number: 104872-42-6
• Molecular Weight: 670.57
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• form: liquid
• packaging: pkg of 1 × 2.5 mL (890898C-25mg); pkg of 2 × 4 mL (890898C-200mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• concentration: 10 mg/mL (890898C-25mg); 25 mg/mL (890898C-200mg)
• application(s): advanced drug delivery
• lipid type: transfection; cationic lipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H]C(C[N+](C)(C)C)(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC.[Cl-]

Description

Application

DOTMA is suitable for use in the synthesis of cationic microbubble.

Biochem/physiol Actions

DOTMA is a cationic lipid used as a non-viral vector for gene therapy. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome - cell membrane interaction.

Packaging

5 mL Clear Glass Sealed Ampule (890898C-200mg)

5 mL Clear Glass Sealed Ampule (890898C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H302,H315,H319,H331,H336,H351,H361d,H372
• Precautionary Statements: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• Target Organs: Liver,Kidney, Respiratory system
• Storage Class Code: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point(F): does not flash
• Flash Point(C): does not flash