845875P

18:1 Lyso PC

Avanti Research^™ - A Croda Brand

• Synonym(s): 1--(9Z-octadecenoyl)-sn-glycero-3-phosphocholine; PC(18:1(9Z)/0:0); 110688
• Empirical Formula (Hill Notation): C₂₆H₅₂NO₇P
• CAS Number: 19420-56-5
• Molecular Weight: 521.67
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• description: 1-oleoyl-2-hydroxy-sn-glycero-3-phosphocholine
• Assay: >99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)
• form: powder
• packaging: pkg of 2 × 100 mg (845875P-200mg); pkg of 5 × 100 mg (845875P-500mg); pkg of 1 × 25 mg (845875P-25mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCC/C=C\CCCCCCCC)=O
• InChI: 1S/C26H52NO7P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26(29)32-23-25(28)24-34-35(30,31)33-22-21-27(2,3)4/h12-13,25,28H,5-11,14-24H2,1-4H3/b13-12-/t25-/m1/s1
• InChI key: YAMUFBLWGFFICM-PTGWMXDISA-N

Description

General description

Lysophosphatidylcholine (LPC) is a lysophospholipid mediator. This bioactive proinflammatory lipid is produced by pathological activities. It is one of the important constituent of oxidized low-density lipoprotein (Ox-LDL).

Application

18:1 Lyso PC is suitable for use as a lysophospholipid mediator to compare the effect of sphingosylphosphorylcholine (SPC). It has been used as a supplement in Yeast nitrogen base (YNB) medium to rescue choline auxotrophy.

Biochem/physiol Actions

Lysophosphatidylcholine (LPC) participates as a key factor in the atherogenic activity of oxidized low-density lipoprotein (Ox-LDL). It alters the roles in endothelial cells, smooth muscle cells, monocytes, macrophages, T-cells, thereby involving in atherosclerosis and inflammatory diseases. LPC activates protein kinase C, extracellular-signal-regulated kinases, protein tyrosine kinases, and Ca(²⁺), that are second messengers.

Packaging

5 mL Clear Glass Sealed Ampule (845875P-200mg)

5 mL Clear Glass Sealed Ampule (845875P-25mg)

5 mL Clear Glass Sealed Ampule (845875P-500mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable