934429
3-((4-(Piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride
≥95%
Synonym(s):
3-((4-(Piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C16H21N3O2 · xHCl
Molecular Weight:
287.36 (free base basis)
UNSPSC Code:
12352200
Recommended Products
Quality Level
Assay
≥95%
form
powder
storage temp.
2-8°C
SMILES string
O=C1NC(C(NC2=CC=C(C=C2)C3CCNCC3)CC1)=O.[xHCl]
Application
A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.
Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Other Notes
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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