920568
tert-Butyl 3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoate
Synonym(s):
Rigid linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C13H21N3O2
Molecular Weight:
251.32
UNSPSC Code:
12352106
NACRES:
NA.22
reaction suitability
reagent type: linker
Quality Level
functional group
ester
storage temp.
2-8°C
SMILES string
CC(C)(OC(CCC1=CN=C2CNCCN12)=O)C
Application
tert-Butyl 3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoate is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920568
920657
ENAH38A2CCD6
AC5372910424
Similar linkers in this series:
920568
920657
ENAH38A2CCD6
AC5372910424
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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