920436
NanoFabTx™ PEG-PLA drug formulation screening kit
for synthesis of PEGylated nanoparticles
Synonym(s):
Microfluidics, NanoFabTx™ reagent kit, Nanoformulation, Nanoparticle kit, PEG-PLA
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.23
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description
Kit components :
PEGPLA-L-M (919942-500mg)
PEGPLA-H-M (919934-500mg)
Stabilizer-Nano (907766-5g)
PEG-PLA drug formulation screening kit, for synthesis of PEGylated PLA nanoparticles
Quality Level
application(s)
advanced drug delivery
storage temp.
2-8°C
General description
NanoFabTx™ PEG-PLA drug formulation screening kit is a nanoformulation kit containing rationally selected PEGylated PLA polymers that have been used widely for controlled drug release of many different types of therapeutic molecules. The kit contains protocols for two different particle synthesis methods:
- A Nanoprecipitation protocol to prepare drug-encapsulated nanoparticles in standard laboratory glassware.
- A Microfluidics protocol using commercial platforms or syringe pumps.
Application
NanoFabTx™ PEG-PLA drug formulation screening kit enables users to encapsulate a wide variety of therapeutic drug molecules in specifically sized, biodegradable, PEGylated PLA nanoparticles. By simplifying the chemistry and providing an easy-to-use toolkit with step-by-step instructions, our NanoFabTx™ nanoformulation screening kit helps researchers achieve reproducible synthesis of drug encapsulating nanoparticles with narrow size dispersity, eliminating the need for lengthy trial-and-error optimization. Suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery, PEG-PLA nanoparticles, made using the NanoFabTx™ PEG-PLA drug formulation screening kit, are designed for maximizing the encapsulation of hydrophobic drugs to minimize the time and expensive wasted reagents of synthetic optimization.
Features and Benefits
- Includes tested protocols with step-by-step instructions for nanoprecipitation or microfluidics-based syntheses
- Requires minimal laboratory setup
- Optimized to achieve monodisperse, homogenously shaped, biodegradable, PEGylated PLA nanoparticles in any size between 60 and 100 nm
- Formulated to maximize the encapsulation of hydrophobic drugs
- Includes two different PEGylated PLAs
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
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Description
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Storage Class Code
10 - Combustible liquids
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Solène Passemard et al.
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Xu Jia et al.
ACS biomaterials science & engineering, 2(9), 1641-1648 (2016-09-12)
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Redouan Mahou et al.
Materials (Basel, Switzerland), 7(1), 275-286 (2014-01-09)
The progress of medical therapies, which rely on the transplantation of microencapsulated living cells, depends on the quality of the encapsulating material. Such material has to be biocompatible, and the microencapsulation process must be simple and not harm the cells.
Sungmin Nam et al.
Biomaterials, 200, 15-24 (2019-02-12)
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S Freiberg et al.
International journal of pharmaceutics, 282(1-2), 1-18 (2004-09-01)
Polymer microspheres can be employed to deliver medication in a rate-controlled and sometimes targeted manner. Medication is released from a microsphere by drug leaching from the polymer or by degradation of the polymer matrix. Since the rate of drug release
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