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911313

Sigma-Aldrich

Poly(ethylene glycol) linear dendron

carboxyl terminated, PEG Mn 10,000, generation 1

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About This Item

Empirical Formula (Hill Notation):
C468H928O237
Molecular Weight:
10348.23
UNSPSC Code:
51171641
NACRES:
NA.23

form

solid

mol wt

PEG Mn 10,000
generation 1

no. Surface Groups

2

color

white to off-white

storage temp.

−20°C

General description

  • Polymer architecture: PEG-linear dendron
  • Generation: 1
  • PEG average Mn: 10,000
  • End Group Functionality: Carboxylic acid
  • No. Surface Groups: 2
  • Calculated Mol. Wt.: 10348.34 g/mol
  • Bis-MPA = 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolyzable linker allows for degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. This dendritic polymer is biocompatible and biodegradable and suitable for biomedical applications. PEG-core dendrons feature excellent solubility in water and a high degree of functionality per PEG chain, making them strong candidates for advanced drug delivery systems or for drug targeting. The carboxylic acid-functionalized corona can be readily used for bioconjugation reactions.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCL3891

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Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications.
Garcia-Gallego S, et al
Progress in Polymer Science, 48, 85-110 (2015)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Articles

The Potential of Dendritic Polyester Scaffolds as Biocompatible Drug Delivery Agents

Professor Michael Malkoch provides an overview of the unique properties of dendritic molecules and their application in biomedical fields. He highlights bis-MPA dendritic scaffolds as a promising biodegradable and biocompatible platform for drug delivery applications

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