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911259

Sigma-Aldrich

Poly(ethylene glycol) linear dendrimer

carboxyl terminated, PEG Mn 10k, generation 3

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About This Item

Empirical Formula (Hill Notation):
C588H1086O318
Molecular Weight:
13244.72
UNSPSC Code:
12352120
NACRES:
NA.23

form

solid

mol wt

PEG Mn 10k
PEG average Mn 10,000
generation 3

no. Surface Groups

16

color

white to off-white

functional group

carboxylic acid

storage temp.

−20°C

General description

  • Polymer architecture: PEG-core dendrimer
  • End Group Functionality: Carboxylic acid
  • Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolyzable linker allows for degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. This dendritic polymer is biocompatible, biodegradable, and suitable for biomedical applications. PEG-core dendrimers feature excellent solubility in water and a high degree of functionality per PEG chain, enabling use for advanced drug delivery systems or for drug targeting. The carboxylic acid-functionalized corona can be readily used for bioconjugation reactions.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications
Progress in Polymer Science, 48, 85-110 (2015)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Articles

The Potential of Dendritic Polyester Scaffolds as Biocompatible Drug Delivery Agents

Professor Michael Malkoch provides an overview of the unique properties of dendritic molecules and their application in biomedical fields. He highlights bis-MPA dendritic scaffolds as a promising biodegradable and biocompatible platform for drug delivery applications

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