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909904

Sigma-Aldrich

4arm-poly(lactide-co-glycolide)

average Mn 38,000-60,000, lactide:glycolide 55:45

Synonym(s):

4 arm PLGA, 4 arm-PLGA, 4arm-PLGA

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About This Item

Linear Formula:
C5H8O4((((C3H4O2)x(C2H2O2)y)m)H)4
UNSPSC Code:
12162002

form

powder or chunks

feed ratio

lactide:glycolide 55:45

mol wt

average Mn 38,000-60,000

color

white to tan

storage temp.

−20°C

Related Categories

Application

Biocompatible and biodegradable polymer. Can be used in the formation of nanoparticles for drug delivery. The multi-arm molecular structure might promote high drug loading, superior colloidal stability, as well as long circulation time.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Xiuxiu Wang et al.
Biomacromolecules, 19(4), 1368-1373 (2018-03-20)
PLGA, a copolymer of lactide and glycolide, is one of the most used biodegradable polymers that find a wide range of biomedical applications including drug delivery and tissue engineering. However, in spite of remarkable advancement, nanotherapeutics based on PLGA might
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these

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