197173
2-Hydrazino-2-imidazoline hydrobromide
98%
Synonym(s):
2-Hydrazino-4,5-dihydroimidazole hydrobromide
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About This Item
Empirical Formula (Hill Notation):
C3H8N4 · HBr
CAS Number:
Molecular Weight:
181.03
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
98%
mp
185-187 °C (lit.)
SMILES string
Br.NNC1=NCCN1
InChI
1S/C3H8N4.BrH/c4-7-3-5-1-2-6-3;/h1-2,4H2,(H2,5,6,7);1H
InChI key
HIJRJVVSABWXKG-UHFFFAOYSA-N
Application
2-Hydrazino-2-imidazoline hydrobromide was used in synthesis of:
- some amide derivatives of 6-(4-carboxymethyloxyphenyl)-4,5-dihydro-3(2H)-pyridazinone
- 2-substituted-6-(4-acylaminophenyl)-4,5-dihydropyridazin-3(2H)-ones, potential inodilating agents
Reactant for synthesis of:
- Molecules that affect vasodilatory activity
- Sulfate-bridges dimerica copper(II) complexes
- 5-HT6 serotonin receptor antagonists
- Pd complexes
- Antidiabetic/antiobesity agents
- DNA binders
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Ranju Bansal et al.
European journal of medicinal chemistry, 44(11), 4441-4447 (2009-07-11)
Synthesis and vasodilatory activity of some amide derivatives of 6-(4-carboxymethyloxyphenyl)-4,5-dihydro-3(2H)-pyridazinone are reported. An effect of substitution at 2-position of pyridazinone ring on vasodilatory potential has also been explored. The most active compound 6-[4-(2-oxo-2-pyrrolidin-1-yl-ethoxy)phenyl]-2-(4-fluorophenyl)-4,5-dihydropyridazin-3(2H)-one (11) exhibited vasodilating activity in nanomolar range
Dinesh Kumar et al.
Acta pharmaceutica (Zagreb, Croatia), 58(4), 393-405 (2008-12-24)
The present study describes the synthesis and pharmacological evaluation of 2-substituted-6-(4-acylaminophenyl)-4,5-dihydropyridazin-3(2H)-ones as potent inodilating agents. The synthesis of target compounds 2-4 and 7-11 was achieved by Friedel-Crafts acylation of appropriate anilide derivative with succinic anhydride or methylsuccinic anhydride and subsequent
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