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V4514

Sigma-Aldrich

Anti-Vesicle Associated Membrane Protein 4, (VAMP4) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
MFCD06798555
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat, mouse

technique(s)

indirect immunofluorescence: 10 μg/mL using CV-1 cells
western blot: 2 μg/mL

UniProt accession no.

O75379

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... VAMP4(8674)
mouse ... Vamp4(53330)
rat ... Vamp4(364033)

General description

Vesicle associated membrane protein 4 (VAMP4) is localized on human chromosome 1q24-q25. It is expressed in the skeletal muscle and liver. The protein is part of the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) family. VAMP4 is localized to the trans-Golgi network.

Specificity

Anti-Vesicle Associated Membrane Protein 4 detectsVAMP-4.

Immunogen

recombinant rat VAMP-4.

Biochem/physiol Actions

Vesicle associated membrane protein 4 (VAMP4) mediates trans-Golgi network trafficking of membrane-bound and secreted proteins. Studies have shown that VAMP4 has a role in maintaining the structure of the Golgi apparatus.

Physical form

Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Akiko Shitara et al.
Molecular biology of the cell, 30(3), 324-332 (2018-12-13)
Lumen establishment and maintenance are fundamental for tubular organs physiological functions. Most of the studies investigating the mechanisms regulating this process have been carried out in cell cultures or in smaller organisms, whereas little has been done in mammalian model
Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish
Mona MS et al
Molecular Genetics and Metabolism, 85(2), 133-139 null
VAMP4 is required to maintain the ribbon structure of the Golgi apparatus
Akiko S et al.
Molecular and Cellular Biochemistry (2013)
Vera Kreykenbohm et al.
European journal of cell biology, 81(5), 273-280 (2002-06-18)
Two mammalian proteins, vtila and vtilb, are homologous to the yeast Q-SNARE Vtilp which is part of several SNARE complexes in different transport steps. In vitro experiments suggest distinct functions for vtila and vtilb. Here we compared the subcellular localization
M Steegmaier et al.
Molecular biology of the cell, 10(6), 1957-1972 (1999-06-08)
The trans-Golgi network (TGN) plays a pivotal role in directing proteins in the secretory pathway to the appropriate cellular destination. VAMP4, a recently discovered member of the vesicle-associated membrane protein (VAMP) family of trafficking proteins, has been suggested to play

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