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T1016

Sigma-Aldrich

Trichlormethiazide

≥98%

Synonym(s):

6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
(+/-)-, NSC 61560

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About This Item

Empirical Formula (Hill Notation):
C8H8Cl3N3O4S2
CAS Number:
133-67-5
Molecular Weight:
380.66
EC Number:
205-118-8
MDL number:
MFCD00057315
UNSPSC Code:
12352200
PubChem Substance ID:
24899924
NACRES:
NA.25

Assay

≥98%

SMILES string

NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl

InChI

1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)

InChI key

LMJSLTNSBFUCMU-UHFFFAOYSA-N

Gene Information

human ... SLC12A3(6559)

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Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334

Precautionary Statements

P261 - P280 - P342 + P311

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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I Kuwajima et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 24(5), 475-480 (2001-10-26)
A randomized prospective controlled study, the National Interventional Cooperative Study in Elderly Hypertensives (NICS-EH), previously demonstrated that the preventive effect of the long-acting calcium channel blocker nicardipine on the cardiovascular endpoint was similar to that of the diuretic, trichlormethiazide. The
Takashi Uzu et al.
Journal of hypertension, 23(4), 861-865 (2005-03-19)
We examined whether thiazide diuretics could restore nocturnal blood pressure (BP) decline and reduce urinary protein excretion in patients with glomerulopathy treated with angiotensin II modulators (angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers). Twenty-five Japanese outpatients (11 men, 14
Kohei Ueda et al.
Internal medicine (Tokyo, Japan), 51(12), 1549-1553 (2012-06-26)
Gitelman's syndrome (GS), an inherited disorder due to loss of function of ion channels and transporters such as Na-Cl co-transporter (NCCT) in distal convoluted tubules, is characterized by hypokalemia, hypomagnesemia, hypocalciuria, metabolic alkalosis and hyperreninemic-hyperaldosteronism. A 39-year-old man was admitted
Kenichiro Miura et al.
Pediatric nephrology (Berlin, Germany), 24(6), 1235-1238 (2009-01-21)
The administration of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin type 1 receptor blockers (ARBs) to pregnant women has been reported to cause ACEI/ARB fetopathy, including oligohydramios, pulmonary hypoplasia, renal insufficiency, limb contracture, and fetal hypotension in the child. Most of
Susumu Ogawa et al.
Hypertension (Dallas, Tex. : 1979), 47(4), 699-705 (2006-03-01)
We tested the hypothesis that blockade of angiotensin II type 1 receptors reduces oxidative stress markers in parallel with urinary albumin and type IV collagen excretions. Sixty-six diabetic patients with nephropathy were randomly assigned to either the angiotensin II receptor
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