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Key Documents

SRP8033

Sigma-Aldrich

IL-1β mouse

recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)

Synonym(s):

Interleukin-1beta, Postn

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

mouse

recombinant

expressed in E. coli

conjugate

untagged

Assay

>95% (SDS-PAGE)

form

lyophilized

mol wt

~17 kDa by SDS-PAGE

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

immunohistochemistry: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white

UniProt accession no.

P10749

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Il1b(16176)

General description

Interleukin-1β (IL-1β) is produced by activated macrophages. It belongs to the IL-1 family of proteins that are involved in the inflammatory response.

Biochem/physiol Actions

Interleukin-1β (IL-1β) stimulates thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation and fibroblast growth factor activity. IL-1β, in most situations requires the inflammasome complex to be cleaved and secreted. This protein may modulate the effects of eosinophils in the intestine.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

Mouse IL-1beta (aa 118-269) is untagged.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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IL-1? in eosinophil-mediated small intestinal homeostasis and IgA production.
Jung Y
Mucosal Immunology, 8(4), 930-942 (2015)
Understanding the mechanism of IL-1? secretion.
Lopez-Castejon G and Brough D
Cytokine & Growth Factor Reviews, 22(4), 189-195 (2011)
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Exposure of pancreatic beta cells to cytokines released by islet-infiltrating immune cells induces alterations in gene expression, leading to impaired insulin secretion and apoptosis in the initial phases of type 1 diabetes. Long non-coding RNAs (lncRNAs) are a new class
Shaffi Manchanda et al.
Molecular and cellular biochemistry, 449(1-2), 63-72 (2018-03-20)
Chronic sleep loss/fragmentation prevalent in the current 24/7 society is associated with irreversible consequences on health and overall wellbeing. Various studies have well documented the ill effects of acute sleep loss on cognitive functions of individuals; however, the underlying mechanism
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