SRP4634

VEGF-C from mouse

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Synonym(s): VEGFC, Vascular Endothelial Growth Factor-C
• MDL number: MFCD03458368
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• biological source: mouse
• recombinant: expressed in E. coli
• Assay: ≥90% (SDS-PAGE)
• form: lyophilized
• potency: >200 ng/mL ED₅₀
• mol wt: ~18.0 kDa
• packaging: pkg of 10 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: endotoxin, tested
• NCBI accession no.: P97953
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... Vegfc(22341)

Description

General description

VEGF-C (vascular endothelial growth factor-C) is a member of the VEGF family of structurally related proteins. The gene encoding this protein is localized on mouse chromosome 8. The product here (VEGF-C from mouse) is a 129 amino acid recombinant protein that lacks the N-terminal and C-terminal extensions and contains only the middle third VEGF homology domain. Mouse VEGF-C exhibits about 85% homology with human and 97% homology with rat VEGF-C.

Biochem/physiol Actions

VEGF-C (vascular endothelial growth factor-C) has a role in lymphangiogenesis. It functions via the VEGF receptor-3 (VEGFR-3). Studies have shown that lymphatic endothelial cells do not form sprouting capillaries without VEGF-C. It has also been observed that this protein stimulates tumor lymphangiogenesis in xenotransplanted and transgenic mouse models of cancer.

Physical form

Lyophilized from acetic solution with 50 μg BSA per 1 μg VEGF-C.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable