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SML0324

Sigma-Aldrich

JW67

≥98% (HPLC)

Synonym(s):

Trispiro[3H-indole-3,2′-[1,3]dioxane-5′,5′′-[1,3]dioxane-2′′,3′′′-[3H]indole]-2,2′′′(1H,1′′′H)-dione (9CI)

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About This Item

Empirical Formula (Hill Notation):
C21H18N2O6
CAS Number:
442644-28-2
Molecular Weight:
394.38
MDL number:
MFCD03036757
UNSPSC Code:
12352200
PubChem Substance ID:
329825329
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

O=C1Nc2ccccc2C13OCC4(CO3)COC5(OC4)C(=O)Nc6ccccc56

InChI

1S/C21H18N2O6/c24-17-20(13-5-1-3-7-15(13)22-17)26-9-19(10-27-20)11-28-21(29-12-19)14-6-2-4-8-16(14)23-18(21)25/h1-8H,9-12H2,(H,22,24)(H,23,25)

InChI key

BTXRSHKJNDFHGA-UHFFFAOYSA-N

Biochem/physiol Actions

JW67 is an efficient and specific inhibitor of the canonical Wnt signaling in vitro and in vivo. It appears that JW67 affects the multiprotein complex consisting of β-catenin/GSK-3b/AXIN/APC/CK1 that controls the degradation of β-catenin. JW67 reduces growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S phase.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Azadeh Yeganeh et al.
Biochimica et biophysica acta, 1861(4), 363-370 (2016-01-19)
Trans-10, cis-12 (t10-c12) CLA treatment reduces lipid accumulation in differentiating mouse and human adipocytes, and decreases fat mass in mice, yet the mechanism of action remains unknown. This study investigated the effect of the cis-9, trans-11 (c9-t11) and t10-c12 CLA
Upasana Sahu et al.
Cell death & disease, 8(3), e2667-e2667 (2017-03-17)
Commensal Escherichia coli has been identified as a major protagonist of microbe-induced colorectal oncogenesis. Its tumour-promoting attribute is linked to the expression of DNA-damaging genotoxins. Using a constitutively invasive variant of non-pathogenic E. coli, we demonstrate that chronic presence of
Zachary P McKay et al.
Journal of immunology (Baltimore, Md. : 1950), 206(6), 1385-1394 (2021-01-29)
Crosstalk between costimulatory and coinhibitory ligands are a prominent node of immune cell regulation. Mounting evidence points toward a critical role for CD155, the poliovirus receptor, in suppressing T cell function, particularly in cancer. However, relative to other known costimulatory/coinhibitory

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