SAB4300623
Anti-Tubulin β-III antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-CFEOM3A, Anti-TUBB3, Anti-TUBB4
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~55 kDa
species reactivity
mouse, human
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(E-E-S-E-A)
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TUBB3(10381)
General description
The antibody detects endogenous level of total Tubulin -βIII protein.
Tubulin β-III (TUBB3) is a constituent of microtubules. It is expressed in mature neurons. It is located on human chromosome 16q24.
Immunogen
Peptide sequence around aa. 442-446 (E-E-S-E-A), according to the protein NP_006077.2
Application
Anti-Tubulin β-III antibody has been used in immunocytochemistry and western blot analysis.
Biochem/physiol Actions
Upregulation of tubulin β-III (TUBB3) shows vigorous tumor characteristics and genetic instability in urinary bladder cancer. It participates in the separation of chromosome. Individuals with congenital fibrosis of the extraocular muscle type 3 (CFEOM3) show mutations in TUBB3. βIII-tubulin modulates glucose metabolism, thereby transforms glucose starvation stress signaling to develop the multiplication of cell and survival in non-small cell lung cancer cells.
Features and Benefits
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Target description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Product No.
Description
Pricing
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Directed differentiation of postnatal hippocampal neural stem cells generates nuclear receptor related-1 protein- and tyrosine hydroxylase-expressing cells
Ding Y, et al.
Molecular Medicine Reports, 14(3), 1993-1999 (2016)
βIII-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells
Parker AL, et al.
Carcinogenesis, 37(8), 787-798 (2016)
?III-tubulin overexpression is linked to aggressive tumor features and genetic instability in urinary bladder cancer
Hinsch A, et al.
Human Pathology, 61, 210-220 (2017)
Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends
Ti SC, et al.
Developmental Cell, 37(1), 72-84 (2016)
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