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Key Documents

SAB4200153

Sigma-Aldrich

Anti-Importin 7 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Synonym(s):

Anti-IMP7, Anti-IPO7, Anti-RANBP7, Anti-Ran-binding protein 7

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

mol wt

antigen ~120 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 2.5-5 μg using lysates of human HEK-293 cells
western blot: 1-2 μg/mL using whole extract of human HeLa cells

UniProt accession no.

Q9H2H9

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SLC38A1(81539)
mouse ... Slc38a1(105727)
rat ... Slc38a1(170567)

General description

Importin 7 is also known as IPO7 and IMP7. It is located on the human chromosome at 12q13.11.

Immunogen

synthetic peptide corresponding to amino acids 2-16 of human Importin 7 conjugated to KLH. The corresponding sequence is identical in mouse and rat Importin 7.

Application

Anti-Importin 7 (N-terminal) antibody has been used in
  • immunoblotting
  • immunoprecipitation
  • western blotting

Biochem/physiol Actions

Importins mediate the nuclear import, for a very diverse set of protein or RNA cargoes. Importin 7 has been identified as an importin for ribosomal protein L23a (rpL23a), histone H1, HIV (Human immunodeficiency virus) reverse transcriptase complex and the zinc finger protein (EZI).

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
060M4812
108M4802

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Importins and exportins: how to get in and out of the nucleus
Weis, Karsten
Trends in Biochemical Sciences, 23(5), 185-189 (1998)
Two-Step Coimmunoprecipitation (TIP) Enables Efficient and Highly Selective Isolation of Native Protein Complexes
Sciuto,M R, et al.
Molecular and Cellular Proteomics, 17(5), 993-993 (2018)
HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome
Zaitseva L, et al.
Retrovirology, 6(1), 11-11 (2009)
S Jäkel et al.
The EMBO journal, 18(9), 2411-2423 (1999-05-06)
Import of proteins into the nucleus proceeds through nuclear pore complexes and is largely mediated by nuclear transport receptors of the importin beta family that use direct RanGTP-binding to regulate the interaction with their cargoes. We investigated nuclear import of
Kristian Almstrup et al.
Cell and tissue research, 322(1), 159-165 (2005-04-23)
Testicular cancer is the most common malignancy among men in the reproductive age and the incidence is increasing, probably caused by environmental factors. Most testicular cancers are testicular germ cell tumours and all originate from a carcinoma in situ (CIS)

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