SAB1408033

Anti-KIAA1706 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

• Synonym(s): EEPD1, Endonuclease/exonuclease/phosphatase family domain containing 1, HSPC107, KIAA1706
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~62.4 kDa
• species reactivity: human
• technique(s): western blot: 1 μg/mL
• NCBI accession no.: BC065518
• UniProt accession no.: Q7L9B9
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... EEPD1(80820)

Description

General description

KIAA1706 is also known as endonuclease-exonuclease-phosphatase family domain containing 1 (EEPD1). The gene is located on human chromosome 7p14.2. This gene contains two helix−hairpin−helix motifs at the N-terminal and an exonuclease/endonuclease/phosphatase domain at the C-terminal end. The protein is localized in the plasma membrane with a myristoylation site in its N terminus.

Immunogen

KIAA1706 (AAH65518.1, 1 a.a. ~ 569 a.a) full-length human protein.

Sequence
MGSTLGCHRSIPRDPSDLSHSRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGSSAQHSPSSLRRDLLAEQQPHHLATAVPLTPRVNINTATPAQLMSVRGLSEKMALSIVDFRREHGPFRSVEDLVRMDGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISTRPSVEAFGGTRDGRPVLRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDREALEKFCTELNQPTLPNIRKWKGPRGCWKAVVAEKPSNQLQKGAGYAGFLWDAAAGMELRDAGSQESSPSNGHGKLAGPSPYLGRFKVGSHDLTLVNLHLAALTLLGSENPSKNHSDGHRLASFAQTLQETLKGEKDVIILGDFGQGPDSNDYDILRKEKFHHLIPAHTFTNISTKNPQGSKSLDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAEFYTEKDWSKKDAPRNGSGVALERSEANIKHER

Biochem/physiol Actions

Endonuclease-exonuclease-phosphatase family domain containing 1 (EEPD1), also known as KIAA1706, acts as a gatekeeper for the repair of stressed replication forks. It maintains the integrity of cell genome by developing safe homologous recombination fork repair pathway. Deficiency of this protein is associated with severe chromosomal abnormalities. The protein acts as a LXR-target gene, which maintains cholesterol efflux and activity of ATP-binding cassette transporter (ABCA1).

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable