R2638
Ribonuclease A, with scrambled disulfide bonds from bovine pancreas
PDI substrate
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About This Item
Recommended Products
biological source
bovine pancreas
form
powder
specific activity
≤2 Kunitz units/mg protein
relevant disease(s)
cancer
storage temp.
−20°C
Application
Ribonuclease A (RNase A) is a pancreatic ribonuclease that cleaves single-stranded RNA. RNase A, and several homologs, may be useful as cancer therapeutics due to their cytotoxic effects on cancer cells. Rnase A is useful in the elucidation of protein structure and absorbance. RNase A has been used as a model system in the study of computer-aided drug design . Product R2638 has scrambled disulfide bonds and is from bovine pancreas.
Biochem/physiol Actions
RNA substrates lie in the cleft of RNase A and are cleaved by histidine 12 and histidine 119, via a 2′-3′ cyclic phosphate intermediate. The intermediate is then stabilized by nearby lysines such as Lys7, Lys41 and Lys66.
Preparation Note
Prepared from Type I-A RNase by the method of Hillson, D.A., et al., Meth. Enzymol., 107, 281 (1984).
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Yan-Long Tang et al.
Experimental and therapeutic medicine, 20(2), 1245-1252 (2020-08-09)
Aging is characterized by a progressive deterioration in metabolic functions. The present study aimed to investigate the antagonistic effects of ginsenoside Rg1 (Rg1) on the γ-ray irradiation-induced aging of mixed hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). C57BL/6
D Joseph-McCarthy et al.
Protein engineering, 9(9), 773-780 (1996-09-01)
One relatively new computational approach to the drug discovery process involves calculating functional group maps of a target structure. Experimental functional group mapping techniques have also recently emerged. In this paper, the structure of RNase A with two bound formates
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