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Key Documents

P5498

Sigma-Aldrich

Anti-Pro-NGF antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-Pro-Nerve Growth Factor

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About This Item

MDL number:
MFCD07370460
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, rat, human

technique(s)

immunohistochemistry: suitable
western blot: 1:200-1:500

UniProt accession no.

P08138

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NGFR(4804)
mouse ... Ngfr(18053)
rat ... Ngfr(24596)

Specificity

Does not cross react with pro-BDNF, pro-NT-3, or mature NGF.

Immunogen

peptide corresponding to amino acid residues 84-104 of rat NGF (precursor). The sequence is identical in mouse and 16/21 residues identical in human.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, 1% BSA and <0.1% sodium azide

Preparation Note

Reconstitute the lyophilized vial with 0.2 ml deionized water.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H312,H412

Precautionary Statements

P273 - P280 - P302 + P352 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Aquatic Chronic 3

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Comparison of nerve growth factor receptor binding models using heterodimeric muteins
Mehta HM et al
Journal of Neuroscience Research, doi: 10-doi: 10 (2012)
M Fahnestock et al.
Molecular and cellular neurosciences, 18(2), 210-220 (2001-08-25)
Nerve growth factor (NGF) is important for regulation, differentiation, and survival of peripheral and central nervous system neurons, including basal forebrain cholinergic neurons (BFCN) which degenerate in Alzheimer's disease (AD). Mature NGF protein is processed from a larger precursor, proNGF.
Death of injured neurons caused by the precursor of nerve growth factor.
Y-A Barde
Proceedings of the National Academy of Sciences of the United States of America, 101(16), 5703-5704 (2004-04-14)
Bai Lu
Neuron, 39(5), 735-738 (2003-09-02)
Neurotrophins are synthesized first as precursors, followed by maturation through proteolytic removal of the "pro" region. Since pro- and mature neurotrophins elicit opposite functional effects by differential interactions with Trks and p75 receptors, extracellular cleavage represents a new way to
Elahe Karimi et al.
Drug design, development and therapy, 13, 2513-2532 (2019-08-24)
Nowadays, the drug delivery system is important in the treatment of diseases. A polymeric nanoparticle modified by oleic acid (NPMO) as a Thymol (Thy) drug release system was synthesized from Thymbra spicata and its neurotrophic and angiogenic effects on rat's
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