MAK213
Neutrophil Elastase Inhibitor Screening Kit
Sufficient for 100 Fluorometric tests
Synonym(s):
Neutrophil Elastase Inhibition Assay Kit
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About This Item
Recommended Products
detection method
fluorometric
storage temp.
−20°C
Gene Information
human ... ELANE(1991)
mouse ... ELANE(50701)
rat ... ELANE(299606)
General description
Neutrophil elastase (NE) is a serine protease that hydrolyzes proteins within the azurophilic granules of the neutrophils. Once secreted, it digests collagen-VI and elastin of the extracellular matrix. Neutrophil elastase is implicated in cystic fibrosis, bronchiectasis, chronic obstructive pulmonary disease, congenital neutropenia, and lung cancer.
Features and Benefits
Compatible with high-throughput handling systems.
Suitability
Suitable for the screening of inhibitors of Neutrophil Elastase.
Principle
The Neutrophil Elastase Inhibitor Screening Kit is a rapid, sensitive and high throughput assay to screen and characterize potential inhibitors of NE. NE activity is measured by hydrolyzing the substrate to yield a fluorescent product (λex = 400/λem = 505 nm) proportional to the enzymatic activity present.
Kit Components Only
Product No.
Description
- Assay Buffer
- Substrate
- Neutrophil Elastase
- Inhibitor Control, 3 mM SPCK
Storage Class Code
10 - Combustible liquids
Certificates of Analysis (COA)
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