K2894
PKAcβ, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
cAPKb
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
423-573 nmol/min·mg
mol wt
~65 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PRKACB(5567)
Biochem/physiol Actions
PRKACB (protein kinase cAMP-activated catalytic subunit β) is a catalytic subunit allele of PKA (protein kinase A). Mutation in it is associated with neural tube defects. PRKACB can phosphorylate p65 in presence of cyclic adenosine monophosphate (cAMP).
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Seiko Susuki-Miyata et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(14), E1800-E1809 (2015-04-02)
Phosphodiesterase 4B (PDE4B) plays a key role in regulating inflammation. Roflumilast, a phosphodiesterase (PDE)4-selective inhibitor, has recently been approved for treating severe chronic obstructive pulmonary disease (COPD) patients with exacerbation. However, there is also clinical evidence suggesting the development of
J Simard et al.
Human genetics, 88(6), 653-657 (1992-03-01)
A cDNA for the human catalytic subunit (C beta) of cAMP-dependent protein kinase (PKA) has been cloned from a testis cDNA library. In the present study, we have determined the chromosomal localization of this gene using a cDNA for C
Jian Wu et al.
International journal of clinical and experimental pathology, 6(12), 2968-2974 (2013-12-03)
This study aimed to investigate the single nucleotide polymorphisms (SNPs) of PKA and neural tube defects (NTDs) in Chinese population. A total of 183 NTDs cases and 200 healthy controls were used in this study. 7 selected single nucleotide polymorphism
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