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Key Documents

J3774

Monoclonal Anti-JAK1 antibody produced in mouse

Name: Monoclonal Anti-JAK1 antibody produced in mouse
Brand: SIGMA

2 mg/mL, clone JAK1-193, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Janus Kinase 1

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About This Item

MDL number:

MFCD00802819

UNSPSC Code:

12352203

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

JAK1-193, monoclonal

form

buffered aqueous solution

mol wt

antigen 130 kDa

species reactivity

rat, human, mouse

concentration

2 mg/mL

technique(s)

indirect ELISA: suitable
microarray: suitable
western blot: 2-4 μg/mL using extract from Raji cells

UniProt accession no.

P23458

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... JAK1(3716)
mouse ... Jak1(16451)
rat ... Jak1(84598)

General description

The Janus kinases (JAKs) are protein tyrosine kinases that modulate cytokine signaling during immunological responses and hematopoiesis. JAK family members consist of four isoforms, namely, JAK1, JAK2, JAK3 and TYK2. JAK1 plays a crucial role in mediating the JAK/STAT signaling response to interleukin 6. Alterations in JAK functions have been implicated in heart and immunological disorders, as well as in hematopoietic malignancies . Monoclonal Anti-JAK1 antibody is specific for human JAK1 (approx. 130 kDa).

Immunogen

The peptide sequence is identical in mouse and rat JAK1.

synthetic peptide corresponding to amino acids 543-555 of human JAK1, conjugated to KLH

Application

Monoclonal Anti-JAK1 antibody is suitable for use in western blot (2-4 μg/mL using extract from Raji cells), indirect ELISA and microarray.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium aside.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Lot/Batch Number

075K4830

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JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.

William Vainchenker et al.

Seminars in cell & developmental biology, 19(4), 385-393 (2008-08-07)

The four mammalian Janus kinase (JAK) family members, JAK1, JAK2, JAK3 and TYK2, are non-receptor protein tyrosine kinases (PTKs) that are crucial for cytokine receptor signaling in blood formation and immune responses. Mutations and translocations in the JAK genes leading

Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains.

Neal K Williams et al.

Journal of molecular biology, 387(1), 219-232 (2009-04-14)

The Janus kinases (JAKs) are a pivotal family of protein tyrosine kinases (PTKs) that play prominent roles in numerous cytokine signaling pathways, with aberrant JAK activity associated with a variety of hematopoietic malignancies, cardiovascular diseases and immune-related disorders. Whereas the

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

D Guschin et al.

The EMBO journal, 14(7), 1421-1429 (1995-04-03)

The protein tyrosine kinases JAK1, JAK2 and Tyk2 and STATs (signal transducers and activators of transcription) 1 and 3 are activated in response to interleukin-6 (IL-6) in human fibrosarcoma cells. In mutant cells lacking JAK1, JAK2 or Tyk2, the absence

Lycorine inhibits cell proliferation and induced oxidative stress-mediated apoptosis via regulation of the JAK/STAT3 signaling pathway in HT-3 cells.

Hui Shang et al.

Journal of biochemical and molecular toxicology, 35(10), e22882-e22882 (2021-09-25)

Human cervical cancer is the fourth most common carcinoma in women in the world. The JAK/STAT3 signaling pathways crucially regulate cell growth and apoptosis. It is a significant target signaling pathway for the development of novel antitumor medicine. This study

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