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I2535

Sigma-Aldrich

InsR (1011-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

CD220, HHF5, Insulin Receptor (1011-end), active, GST tagged

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

Assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

2281-3086 nmol/min·mg

mol wt

~70 kDa

UniProt accession no.

P06213

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... INSR(3643)

Biochem/physiol Actions

INSR (insulin receptor) belongs to the receptor tyrosine kinase family and is a cell surface receptor. Insulin binding to INSR results in autophosphorylation and increased catalytic activity. These events are important for downstream signalling. Insulin/INSR signaling is crucial in the central nervous system for controlling blood glucose levels, synaptic plasticity, dendritic growth, regulation of electrophysiological activity, astrocytes proliferation and neuronal cell death. Mutations in INSR are associated with hyperinsulinemic hypoglycemia syndrome.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLBH0038V
SLBD3733V
SLBB7291V

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Matthew J Brady
The Journal of clinical investigation, 114(7), 886-888 (2004-10-07)
The etiology of type 2 diabetes is characterized by obesity, insulin and leptin resistance, and compensatory beta cell hyperplasia followed by islet degeneration, resulting in the eventual dysregulation of glucose and lipid homeostasis. The recent identification of insulin receptor substrate
Fengyuan Che et al.
Seizure, 25, 178-180 (2014-12-03)
Insulin/insulin receptor (INSR) signaling plays diverse roles in the central nervous system, including regulation of blood glucose, synaptic plasticity, dendritic growth, modulation of electrophysiological activity, proliferation of astrocytes and neuronal apoptosis. Interestingly, many of these and/or related processes represent biological
Yohei Kuroda et al.
Endocrine journal, 62(4), 353-362 (2015-03-11)
Insulinoma and insulin or insulin receptor (IR) autoantibodies are the main causes of hyperinsulinemic hypoglycemia in adults, but the exact cause in other cases remains obscure. This study is to determine the genetic basis of hyperinsulinemic hypoglycemia in two cases
Haruka Okamoto et al.
The Journal of clinical investigation, 114(2), 214-223 (2004-07-16)
The role of different tissues in insulin action and their contribution to the pathogenesis of diabetes remain unclear. To examine this question, we have used genetic reconstitution experiments in mice. Genetic ablation of insulin receptors causes early postnatal death from
M Zulema Cabail et al.
Nature communications, 6, 6406-6406 (2015-03-12)
The insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) are highly related receptor tyrosine kinases with a disulfide-linked homodimeric architecture. Ligand binding to the receptor ectodomain triggers tyrosine autophosphorylation of the cytoplasmic domains, which stimulates catalytic activity and creates

Articles

Insulin Signaling and Energy Homeostasis

Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism through its actions on muscle, liver, and adipose tissue.

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