G8032
Gelsolin from bovine plasma
≥95% (SDS-PAGE), lyophilized powder
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About This Item
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Assay
≥95% (SDS-PAGE)
form
lyophilized powder
specific activity
20-100 units/mg protein
mol wt
74 kDa
composition
Protein, ≤10%
solubility
soluble 10 imidazole mg/mL
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... GSN(280810)
Application
Gelsolin from bovine plasma was used in actin assembly assays.
Biochem/physiol Actions
Gelsolin is an actin-binding protein that regulates the assembly and disassembly of actin filaments.
Gelsolin is an actin-severing protein found in mammalian cells and blood plasma. Exhibits tumor suppressor activity in several cancer cell lines and in nude mice.
Packaging
Package size based on protein content
Unit Definition
One unit will reduce viscosity difference between actin solution and buffer by 50% in a 1 mL mixture containing 1-2mg F-actin, 0.15 M KCl, 20 mM Tris, pH 7.6, 0.2 mM CaCl2, 0.2 mM ATP, and 1 mM DTT at 28 °C.
Physical form
Lyophilized powder containing NaCl, Tris buffer salt, and EGTA
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Markus Ganter et al.
Molecular microbiology, 74(6), 1356-1367 (2009-08-18)
Summary Successful malaria transmission from the mosquito vector to the mammalian host depends crucially on active sporozoite motility. Sporozoite locomotion and host cell invasion are driven by the parasite's own actin/myosin motor. A unique feature of this motor machinery is
Takehito Uruno et al.
The Journal of biological chemistry, 281(15), 10635-10650 (2006-01-26)
Acanthamoeba CARMIL was previously shown to co-purify with capping protein (CP) and to bind pure CP. Here we show that this interaction inhibits the barbed end-capping activity of CP. Even more strikingly, this interaction drives the uncapping of actin filaments
R C Koya et al.
The Journal of biological chemistry, 275(20), 15343-15349 (2000-05-16)
Apoptotic cell death, characterized by chromatin condensation, nuclear fragmentation, cell membrane blebbing, and apoptotic body formation, is also accompanied by typical mitochondrial changes. The latter includes enhanced membrane permeability, fall in mitochondrial membrane potential (Deltapsi(m)) and release of cytochrome c
Gelsolin, a multifunctional actin regulatory protein.
H Q Sun et al.
The Journal of biological chemistry, 274(47), 33179-33182 (1999-11-24)
Nikolaos Parisis et al.
The EMBO journal, 36(21), 3212-3231 (2017-10-07)
Nuclear actin regulates transcriptional programmes in a manner dependent on its levels and polymerisation state. This dynamics is determined by the balance of nucleocytoplasmic shuttling, formin- and redox-dependent filament polymerisation. Here, using
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