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74148

Sigma-Aldrich

D-myo-Inositol 1,4,5-triphosphate tripotassium salt

≥80% (HPLC)

Synonym(s):

Ins(1,4,5)P3

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About This Item

Empirical Formula (Hill Notation):
C6H12K3O15P3
CAS Number:
141611-11-2
Molecular Weight:
534.37
MDL number:
MFCD00221525
UNSPSC Code:
12352108
PubChem Substance ID:
329765502
NACRES:
NA.32

Assay

≥80% (HPLC)

form

solid

storage temp.

−20°C

SMILES string

O[C@@H]1[C@@H](OP(O)([O-])=O)[C@H](OP(O)([O-])=O)[C@@H](O)[C@@H](O)[C@H]1OP(O)([O-])=O.[K+].[K+].[K+]

InChI

1S/C6H15O15P3.3K/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12;;;/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t1-,2+,3+,4-,5-,6-;;;/m1.../s1

InChI key

MQMSEISCCNPXIL-ZKVWPJASSA-K

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCBV5583
BCBS6296V
BCBQ6889V
BCBL4869V

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Francis Wolfram et al.
The Biochemical journal, 428(3), 483-489 (2010-04-10)
IP3Rs (inositol 1,4,5-trisphosphate receptors) are the intracellular channels that mediate release of Ca2+ from the endoplasmic reticulum in response to the many stimuli that evoke Ins(1,4,5)P3 formation. We characterized and purified type 1 IP3R heterologously expressed in Sf9 insect cells
I-Shan Chen et al.
Journal of biomedical science, 18, 2-2 (2011-01-08)
This study investigates whether protein kinase G (PKG), protein kinase A (PKA) and protein kinase C (PKC) are involved in the regulatory mechanisms of store-operated channel (SOC) in pulmonary arteries. Pulmonary artery smooth muscle cells (PASMCs) were enzymatically dissociated from
M Hirata et al.
The Journal of biological chemistry, 264(34), 20303-20308 (1989-12-05)
A series of inositol 1,4,5-trisphosphate (IP3) analogs and positional isomers was examined to explore the structure-activity relationships among IP3 5-phosphatase, IP3 3-kinase, and the release of Ca2+. All analogs with additional groups on the 2nd position of IP3 inhibited the
Robert Duliński et al.
Biomolecules, 10(2) (2020-01-25)
A relatively high concentration of phytate in buckwheat malt, and the low activity of endogenous buckwheat phytases, both of which limit the effective use of substrates (starch, proteins, minerals) for fermentation and yeast metabolism, gives rise to the potential for
Igor Cestari et al.
Molecular biology of the cell, 29(9), 1137-1152 (2018-03-09)
Many cellular processes change during the Trypanosoma brucei life cycle as this parasite alternates between the mammalian host and tsetse fly vector. We show that the inositol phosphate pathway helps regulate these developmental changes. Knockdown of inositol polyphosphate multikinase (IPMK)
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