T8656
Thiourea
ACS reagent, ≥99.0%
Synonym(s):
Sulfourea, Thiocarbamide
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About This Item
Linear Formula:
NH2CSNH2
CAS Number:
Molecular Weight:
76.12
Beilstein:
605327
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.21
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grade
ACS reagent
Quality Level
Assay
≥99.0%
ign. residue
≤0.1% (as SO4)
loss
≤0.5% loss on drying, 105°C, 2h
mp
170-176 °C (lit.)
174-177 °C
solubility
H2O: passes test
SMILES string
NC(N)=S
InChI
1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
InChI key
UMGDCJDMYOKAJW-UHFFFAOYSA-N
Gene Information
mouse ... Ephx2(13850)
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General description
Thiourea is an analogue of urea containing sulphur.
Application
Thiourea has been used:
- as a component of lysis buffer for liver tissue homogenization
- in 2-D sample buffer for two-dimensional in-gel protein tyrosine phosphatases (PTP) assay
- in rehydration buffer for protein extraction
Chaotropic agent; strong denaturant. Increases solubility and recovery of proteins
Biochem/physiol Actions
Thiourea is a free radical scavenger of the peroxide radical. It was shown to inhibit lipid peroxidation and ultraviolet (UV)-induced crosslinking of collagen. Bud dormancy in plants can be inhibited by thiourea which is used as a growth stimulator. It is also known to be used in the treatment of hyperthyroidism.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Effect of copper nanoparticles exposure in the physiology of the common carp (Cyprinus carpio): Biochemical, histological and proteomic approaches
Gupta YR, et al.
Aquaculture and Fisheries, 1(2), 15-23 (2016)
Mechanism of the reduction of methylene blue by thiourea in aqueous acidic medium
Osunlaja AA
International Journal of ChemTech Research, 4(2), 609-617 (2012)
Nisha Singh et al.
Frontiers in plant science, 6, 606-606 (2015-08-25)
Pigeonpea is an important legume crop with high protein content. However, it is often subjected to various abiotic and biotic stresses. Proteomics is a state-of-the-art technique used to analyze the protein profiling of a tissue for deciphering the molecular entities
Investigation of protein-tyrosine phosphatases by in-gel assays.
Markova B, et al.
Methods, 35(1), 22-27 (2005)
Elaine M Boyle et al.
The Journal of organic chemistry, 78(17), 8312-8319 (2013-08-01)
Thiourea-functionalized Tröger's base receptors 1 and 2 have been synthesized and evaluated as novel for the recognition of anions. Receptor 2 gave rise to significant changes in the absorption spectrum upon titration with AcO(-) and H2PO4(-) and acted as a
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