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P9422

Supelco

Pramoxine hydrochloride

analytical standard, ≥98%

Synonym(s):

4-[3-(4-Butoxyphenoxy)propyl]morpholine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H27NO3 · HCl
CAS Number:
637-58-1
Molecular Weight:
329.86
EC Number:
211-293-1
MDL number:
MFCD00054323
UNSPSC Code:
41116107
PubChem Substance ID:
329820349
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥98%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cl.CCCCOc1ccc(OCCCN2CCOCC2)cc1

InChI

1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H

InChI key

SYCBXBCPLUFJID-UHFFFAOYSA-N

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General description

Pramoxine hydrochloride is a surface and local anesthetic agent , which provides relief from itching and pain for a short period of time.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Topical anesthetic for skin or mucous membranes

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCK0443
MKBX9397V
MKBS0878V
SLBD7175V
091M1342V

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Contact dermatitis from prilocaine with cross-sensitivity to pramocaine and bupivacaine.
Fernando García et al.
Contact dermatitis, 56(2), 120-121 (2007-01-25)
Trudye A Young et al.
The Journal of dermatological treatment, 20(2), 76-81 (2008-09-30)
The objective of this study was to evaluate the efficacy of a commercially available anti-itch lotion containing 1% pramoxine hydrochloride versus control lotion in the treatment of uremic pruritus in adult hemodialysis patients. This was a randomized, double-blind, controlled comparative
Allergic reactions to topical (surface) anesthetics with reference to the safety of tronothane (pramoxine hydrochloride).
A A Fisher
Cutis, 25(6), 584-584 (1980-06-01)
Tronolane (pramoxine).
The Medical letter on drugs and therapeutics, 23(23), 100-100 (1981-11-13)
Aerlyn Dawn et al.
Dermatology nursing, 18(3), 227-233 (2006-07-22)
Itch is an important, but underestimated symptom in psoriasis. Many therapies are available for pruritus; however, few are effective for psoriatic itch. Antipruritic therapies that are potentially effective in psoriasis include coal tar products, topical corticosteroids, topical salicylates, menthol and
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