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52448

Supelco

Ranitidine S-oxide

pharmaceutical impurity standard, ≥95.0% (HPLC)

Synonym(s):

Ranitidine Related Compound C (USP), Ranitidine impurity C (PhEur), N-{2-{{{5-[(Dimethylamino)methyl]furan-2-yl}methyl}sulfinyl}ethyl}-N′-methyl-2-nitroethene-1,1-diamine

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About This Item

Empirical Formula (Hill Notation):
C13H22N4O4S
CAS Number:
73851-70-4
Molecular Weight:
330.40
Beilstein:
8395257
MDL number:
MFCD08063699
UNSPSC Code:
41116107
PubChem Substance ID:
329757841

grade

analytical standard

Assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤10.0% related substances
≤5.0% solvents
≤5.0% water

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CN\C(NCCS(=O)Cc1ccc(CN(C)C)o1)=C/[N+]([O-])=O

InChI

1S/C13H22N4O4S/c1-14-13(9-17(18)19)15-6-7-22(20)10-12-5-4-11(21-12)8-16(2)3/h4-5,9,14-15H,6-8,10H2,1-3H3/b13-9+

InChI key

SKHXRNHSZTXSLP-UKTHLTGXSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H317,H334,H335

Precautionary Statements

P280 - P302 + P352

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCBS7735V

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J H Kang et al.
Pharmacogenetics, 10(1), 67-78 (2000-03-30)
A non-invasive urine analysis method to determine the in-vivo flavin-containing mono-oxygenase (FMO) activity catalysing N-oxidation of ranitidine (RA) was developed and used to phenotype a Korean population. FMO activity was assessed by the molar concentration ratio of RA and RANO
P Viñas et al.
Journal of chromatography. B, Biomedical sciences and applications, 693(2), 443-449 (1997-06-06)
Ranitidine and its main metabolites, ranitidine N-oxide and ranitidine S-oxide, were determined in plasma and urine after separation using reversed-phase liquid chromatography. The mobile phase consisted of an initial isocratic step with 7:93 (v/v) acetonitrile-7.5 mM phosphate buffer (pH 6)
M H Davies et al.
Journal of hepatology, 22(5), 551-560 (1995-05-01)
We have previously reported an association of impaired S-oxidation with primary biliary cirrhosis. In order to confirm and further define this relationship, we retested S-oxidation capacity via three metabolic pathways and sulphation capacity via a fourth pathway. Metabolism of S-carboxymethyl-L-cysteine
M S Lant et al.
Journal of chromatography, 323(1), 143-152 (1985-04-17)
Reversed-phase high-performance liquid chromatography systems for the separation of ranitidine and its metabolites ranitidine-N-oxide, ranitidine-S-oxide, and desmethylranitidine have been developed for use in high-performance liquid chromatography-mass spectrometry. A direct liquid introduction-high-performance liquid chromatography-mass spectrometry system to analyse qualitatively and quantitatively

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