582231
Tetanus Toxoid, Clostridium tetani
This tetanus toxoid is prepared by formaldehyde inactivation of tetanus toxin. It retains its antigenic character, but is essentially nontoxic as determined by an LD₅₀ in mice.
Synonym(s):
TTx
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
shipped in
ambient
storage temp.
2-8°C
Biochem/physiol Actions
Tetanus Toxoid acts against Clostridium tetani, a gram-positive bacillus that produces a neurotoxin called tetanospasmin. Tetanospasmin prevents the release of an inhibitory neurotransmitter and causes unopposed muscle contractions and spasms. Tetanus toxoid vaccine stimulates the immune system to respond to the vaccine’s antigens. The immune system’s T-lymphocytes (TH2 and B cells) secrete immunoglobulin against the antigen in the vaccine. This immunoglobulin helps to protect against future infections.
Warning
Toxicity: Standard Handling (A)
Physical form
Lyophilized from 100 mM histidine, 100 mM NaCl, 5% trehalose, pH 7.0.
Reconstitution
Reconstitute in 50 µl of sterile distilled H₂O
Other Notes
Wrenger, S., et al. 2000. J. Biol. Chem.275, 22180.
Habermann E. and Goretzki, K. 1985. In Monoclonal Antibodies Against Bacteria (Macario, A.J.L., and Conway de Macario, E. eds.) Academic Press, New York, p.191.
Kozbor, D. and Roder, J.C. 1981. J. Immunol.127, 1275.
Bizzini, B., et al. 1970. Eur. J. Biochem.17, 100.
Largier, J.F. and Joubert, F.J. 1956. Biochem. Biophys. Acta20, 407.
Habermann E. and Goretzki, K. 1985. In Monoclonal Antibodies Against Bacteria (Macario, A.J.L., and Conway de Macario, E. eds.) Academic Press, New York, p.191.
Kozbor, D. and Roder, J.C. 1981. J. Immunol.127, 1275.
Bizzini, B., et al. 1970. Eur. J. Biochem.17, 100.
Largier, J.F. and Joubert, F.J. 1956. Biochem. Biophys. Acta20, 407.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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