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559276

Sigma-Aldrich

Ryanodine

≥98% (HPLC), solid, Ca2+ release blocker, Calbiochem®

Synonym(s):

Ryanodine, High Purity

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About This Item

Empirical Formula (Hill Notation):
C25H35NO9
CAS Number:
15662-33-6
Molecular Weight:
493.55
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Ryanodine, High Purity, Naturally occurring alkaloid that blocks the release of Ca2+ from the sarcoplasmic reticulum.

Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 1 mg/mL
methanol: 20 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19-,20-,21-,22+,23+,24+,25+/m0/s1

InChI key

JJSYXNQGLHBRRK-YSOSZROBSA-N

General description

Naturally occurring alkaloid that blocks the release of Ca2+ from the sarcoplasmic reticulum. Has many complex effects on Ca2+ transport and action in muscle.
Naturally occurring alkaloid that blocks the release of Ca2+ from the sarcoplasmic reticulum. Has many complex effects on Ca2+ transport and action in muscle. Purified from Ryanodine Mixture.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Ca2+ transport and action in muscle
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.

Other Notes

Sorrentino, V., and Volpe, P. 1993. Trends Pharmacol. Sci.14, 98.
Sabbadini, R., et al. 1992. J. Biol. Chem.267, 15475.
Feher, J.J., and Lipford, G.B. 1985. Biochim. Biophys. Acta813, 77.
Marban, E., and Wier, W.G. 1985. Circ. Res.56, 133.
Sukto, J.L., et al. 1985. Fed. Proc.44, 2984.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302 + H312,H410

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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