5.06239

Bupropion Hydrochloride

• Synonym(s): Bupropion Hydrochloride, Dopamine and noradrenalin Transporter Inibitor, Bupropion
• Empirical Formula (Hill Notation): C₁₃H₁₈ClNO · xHCl
• CAS Number: 31677-93-7
• Molecular Weight: 239.74 (free base basis)
• MDL number: MFCD00055209
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• potency: 1.4 μM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: water: soluble
• storage temp.: 2-8°C
• InChI: 1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H
• InChI key: HEYVINCGKDONRU-UHFFFAOYSA-N

Description

General description

A non-selective inhibitor of dopamine and noradrenalin transporters (K_i = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC₅₀ = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.

Biochem/physiol Actions

Primary Target
DAT/NET

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Budzynska, B. et al. 2011 Pharmacol. Rep.63, 71.

Dwoskin, P., et al. 2006. CNS Drug Rev.12, 178.
Soroko, F., et al. 1977. J. Pharm. Pharmacol.29, 769.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable