191501

1-Azakenpaullone

InSolution, ≥94%, ATP-competitive inhibitor of GSK-3Beta

• Synonym(s): InSolution 1-Azakenpaullone
• Empirical Formula (Hill Notation): C₁₅H₁₀BrN₃O
• CAS Number: 676596-65-9
• Molecular Weight: 328.16
• MDL number: MFCD09037522
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥94% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
• InChI key: NTSBZVCEIVPKBJ-UHFFFAOYSA-N

Description

General description

A Kenpaullone (>Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC₅₀ = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC₅₀ = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
GSK-3β

Reversible: yes

Target IC₅₀: 18 nM for GSK-3&beta

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

A 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.

Other Notes

Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett.14, 413.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 188.6 °F - (refers to pure substance)
• Flash Point(C): 87 °C - (refers to pure substance)