165350
PARP Inhibitor I, 3-ABA
The PARP Inhibitor I, 3-ABA, also referenced under CAS 3544-24-9, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
Synonym(s):
PARP Inhibitor I, 3-ABA, 3-Aminobenzamide
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About This Item
Empirical Formula (Hill Notation):
C7H8N2O
CAS Number:
Molecular Weight:
136.15
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥99% (GC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
ethanol: 1 mg/mL
water: 1 mg/mL
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
10-30°C
InChI
1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
InChI key
GSCPDZHWVNUUFI-UHFFFAOYSA-N
General description
A cell-permeable anti-proliferative agent that acts as an inhibitor of poly(ADP-ribose) polymerase (PARP). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. An inhibitor of UV-induced apoptosis. Also strongly inhibits K562 target cell killing by human effector natural killer cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PARP
PARP
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Irritant (B)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C ). Stock solutions are stable for 3 months at -20°C.
Other Notes
Tiozzo, R., et al. 1996. Biochem. Biophys. Res. Commun. 225, 826.
Malorni, W., et al. 1995. Biochem. Biophys. Res. Commun. 207, 715.
Malorni, W., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1250.
Monti, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 525.
Kozak, K.R., and Ross, I.A. 1991. Biochem. Biophys. Res. Commun.179, 1225.
Malorni, W., et al. 1995. Biochem. Biophys. Res. Commun. 207, 715.
Malorni, W., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1250.
Monti, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 525.
Kozak, K.R., and Ross, I.A. 1991. Biochem. Biophys. Res. Commun.179, 1225.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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