1.20079

Eshmuno^® Q Resin

Eshmuno® Q

• Synonym(s): Eshmuno^® Q
• UNSPSC Code: 47101511

Properties

• Quality Level: 400
• ligand: (Trimethylammoniumethyl)
• sterility: sterile (Caustic Stable)
• product line: Eshmuno^®
• form: resin
• specific analyte(s): MAbs
• parameter: 1000 cm/hr flow rate; 1000 cm/hr max. flow rate; 8 bar max. pressure
• matrix active group: polymer, polyvinyl ether
• mean particle size: 85 μm
• capacity: 150 mg binding capacity (BSA/mg of resin); ~150 mg, BSA binding capacity
• transition temp: flash point 35 °C (own results)
• density: 1 g/cm³ at 20 °C
• application(s): recombinant protein; vaccine development
• separation technique: anion exchange; mixed mode
• storage temp.: 2-30°C

Description

General description

Eshmuno^® Q resin is a strong anion exchange resin, coupling our renowned tentacle structure with a hydrophilic polyvinyl ether base matrix. Consequently, Eshmuno^® Q resin offers outstanding results in typical anion exchange applications, such as removing biomolecules′ impurities in flow-through mode.

Features and Benefits

Eshmuno^® Q chromatography resin enables:

• Purification of acidic and neutral proteins and peptides from different sources, including plasma

Superior productivity for downstream processing of biomolecules

• High flow rate versus pressure-flow behavior
• Excellent removal of impurities, such as HCP, leached Protein A, and viruses
• Robust and safe packing procedures
• Strong chemical stability

Packaging

• 1.20079.0100: Eshmuno^® Q Resin 100ml
• 1.20079.0010: Eshmuno^® Q Resin 10ml
• 1.20079.0500: Eshmuno^® Q Resin 500ml
• 1.20079.5000: Eshmuno^® Q Resin 5L

Plastic bottle

Analysis Note

Appearance: Milky cream coloured turbid suspension, free from coarse mechanical impurities.
Microscopic evaluation: Spherical particles, no agglomerates, no fines.
Extractable matter (water): ≤ 0.08 %
Ionic capacity: 90 - 190 µeq/ml
Performance test (conalbumin): 9 - 19 mS/cm
Performance test (human serum albumin): 20 - 30 mS/cm
Pressure drop(column: ID=1.6 cm, L=10 cm at 5 ml/min): ≤ 1.0 bar
Protein binding capacity(bovine serum albumin): 120 - 190 mg/ml
Particle size (50-120 µm): ≥ 80 %
Particle size (d50): 75 - 95 µm
Cerium: ≤ 30 µg/g
Endotoxins: ≤ 1.00 EU/ml
TAMC (total aerobic microbial count): ≤ 100 CFU/ml
TYMC (total yeast and mould count): ≤ 100 CFU/ml

Legal Information

Eshmuno is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02
• Signal Word: Warning
• Hazard Statements: H226
• Precautionary Statements: P210 - P233 - P240 - P241 - P242 - P243
• Hazard Classifications: Flam. Liq. 3
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 95.0 °F
• Flash Point(C): 35 °C