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Key Documents

06-1425

Sigma-Aldrich

Anti-phospho-TAK1 (Ser412) Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse

technique(s)

western blot: suitable

NCBI accession no.

NP_663306

UniProt accession no.

O43318

shipped in

wet ice

target post-translational modification

phosphorylation (pSer412)

Gene Information

human ... MAP3K7(6885)

General description

TAK1 MAPKKK is activated by TAB1 to transform growth factor-beta (TGF-beta) signaling. TAK1 can also associate with TAB1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. TAK1 has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways.

Specificity

This antibody recognizes TAK1 phosphorylated at Ser412.

Immunogen

Epitope: Phosphorylated Ser412
KLH-conjugated linear peptide corresponding to human TAK1 phosphorylated at Ser412.

Application

Detect phospho-TAK1 (Ser412) using this Anti-phospho-TAK1 (Ser412) Antibody validated for use in WB.

Quality

Evaluated by Western Blot in lambda phosphatase treated and untreated Murine RAW cell lysates.

Western Blot Analysis: 1 µg/mL of this antibody detected TAK1 on 10 µg of lambda phosphatase treated and untreated Murine RAW cell lysates.

Target description

~70 kDa observed

Analysis Note

Control
Lambda phosphatase treated and untreated Murine RAW cell lysates

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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